Publications
2024
Obr M, Percipalle M, Chernikova D, Yang H, Thader A, Pinke G, Porley D, Mansky LM, Dick RA, Schur FKM
Distinct stabilization of the human T-cell leukemia virus type 1 immature Gag lattice
Nature Structural & Molecular Biology (2024), https://doi.org/10.1038/s41594-024-01390-8
Initially available as BioRxiv preprint
Zens B, Fäßler F, Hansen JM, Hauschild R, Datler J, Hodirnau V-V, Zheden V, Alanko J, Sixt M, Schur FKM
Lift-out cryo-FIBSEM and cryo-ET reveal the ultrastructural landscape of extracellular matrix
Journal of Cell Biology (2024), https://doi.org/10.1083/jcb.202309125
Initially available as BioRxiv preprint
Datler J*, Hansen JM*, Thader A, Schlögl A, Bauer LW, Hodirnau VV, Schur FKM
Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores
Nature Structural & Molecular Biology (2024), https://doi.org/10.1038/s41594-023-01201-6
Initially available as BioRxiv preprint
2023
Koch J, Xin Q, Obr M, Schäfer A, Rolfs N, Anagho H, Kudulyte A, Woltereck L, Kummer S, Campos J, Uckeley ZM, Bell-Sakyi L, Kräusslich H-G, Schur FKM, Acuna C, Lozach PY
The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells
PLOS Pathogens (2023), https://doi.org/10.1371/journal.ppat.1011562
Initially available as BioRxiv preprint
Fäßler F, Javoor MG, Schur FKM
Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM
Biochemical Society Transactions (2023), https://doi.org/10.1042/BST20220221
Fäßler F, Javoor MG, Datler J, Döring H, Hofer FW, Dimchev G, Hodirnau VV, Faix J, Rottner K, Schur FKM
ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning
Science Advances (2023), DOI: 10.1126/sciadv.add6495
Initially available as BioRxiv preprint
2022
Nicolas WJ, Fäßler F, Dutka P, Schur FKM, Jensen GJ, Meyerowitz EM
Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks
Current Biology (2022), https://doi.org/10.1016/j.cub.2022.04.024
Initially available as BioRxiv preprint
Obr M, Hagen WJH, Dick RA, Yu L, Kotecha A, Schur FKM
Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs
Journal of Structural Biology (2022), https://doi.org/10.1101/2022.01.10.475481
Initially available as BioRxiv preprint
Windhaber S, Xin Q, Uckeley ZM, Koch J, Obr M, Garnier C, Luengo-Guyonnot C, Duboeuf M, Schur FKM, Lozach PY
The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes
Journal of Virology (2022), https://doi.org/10.1128/jvi.02146-21
2021
Dimchev G*, Amiri B*, Fäßler F, Falcke M, Schur FKM
Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data
Journal of Structural Biology (2021), https://doi.org/10.1016/j.jsb.2021.107808
Initially available as BioRxiv preprint
Obr M, Schur FKM#, Dick RA#
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly
Viruses (2021), 13(9), 1853; https://doi.org/10.3390/v13091853
Obr M, Ricana CL, Nikulin N, Feathers JR, Klanschnig M, Thader A, Johnson MC, Vogt VM, Schur FKM#, Dick RA#
Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer
Nature Communications (2021), doi.org/10.1038/s41467-021-23506-0
Initially available as BioRxiv preprint
Morandell JA, Schwarz LA, Basilico B, Tasciyan S, Dimchev G, Nicolas A, Sommer C, Kreuzinger C, Dotter CP, Knaus LS, Dobler Z, Cacci E, Schur FKM, Danzl JG, Novarino G
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
Nature Communications (2021), doi.org/10.1038/s41467-021-23123-x
2020
Fäßler F, Dimchev G, Hodirnau VV, Wan W, Schur FKM
Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction
Nature Communications (2020) 11, 6437, doi.org/10.1038/s41467-020-20286-x
Initially available as BioRxiv preprint
Fäßler F*, Zens B*., Hauschild R, Schur FKM
3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy
Journal of Structural Biology (2020), 212, 107633, doi.org/10.1016/j.jsb.2020.107633
Initially available as BioRxiv preprint
Hadzijusufovic E, Keller A, Berger A, Greiner G, Wingelhofer B, Witzeneder N, Ivanov D, Pecnard E, Nivarthi H, Schur FKM, Filik Y, Kornauth C, Neubauer HA, Müllauer L, Tin G, Park J, de Araujo ED, Gunning PT, Hoermann G, Gouilleux F, Kralovics R, Moriggl R, Valent P
STAT5 is Expressed in CD34+/CD38− Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms
Cancers (2020), 12(4), 1021, doi.org/10.3390/cancers12041021
Dick RA*#, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers JR, Johnson MC, Vogt VM, Perilla JR, Briggs JAG, Schur FKM*#
Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly
PLOS Pathogens (2020), 16, e1008277, doi:10.1371/journal.ppat.1008277
2019
Obr M, Schur FKM
Structural Analysis of pleomorphic and asymmetric viruses using cryo-electron tomography and subtomogram averaging
Advances in Virus Research (2019), doi: 10.1016/bs.aivir.2019.07.008
Schur FKM
Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging
Current Opinion in Structural Biology (2019), 58, 1-9, doi: 10.1016/j.sbi.2019.03.018
2018
Qu K, Glass B, Doležal M, Schur FKM, Murciano B, Rein A, Rumlová M, Ruml T, Kräusslich H-G, Briggs JAG
Structure and architecture of immature and mature murine leukemia virus capsids
PNAS (2018), 115(50), E11751–E11760, doi: 10.1073/pnas.1811580115
Dick RA, Zadrozny KK, Xu C, Schur FKM, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser-Pornillos BK, Johnson MC, Pornillos O, Vogt VM
Inositol phosphates are assembly co-factors for HIV-1
Nature (2018), 560:509-512. doi: 10.1038/s41586-018-0396-4
2017
Turonova B, Schur FKM, Wan W, Briggs JAG
Efficient 3D-CTF correction for cryo-electron tomography using NovaCTF improves subtomogram averaging resolution to 3.4 Å
Journal of Structural Biology (2017), 199(3); 187-105. doi:10.1016/j.jsb.2017.07.007
2016
Leithner A, Eichner A, Müller J, Reversat A, Brown M, Schwarz J, Merrin J, de Gorter DJ, Schur F, Bayerl J, de Vries I, Wieser S, Hauschild R, Lai FPL, Moser M, Kerjaschki D, Rottner K, Small JV, Stradal TEB, Sixt M
Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes
Nature Cell Biology (2016), 8(11):1253-1259. doi:10.1038/ncb3426
Schur FKM, Obr M, Hagen WJH, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kräusslich H-G, Briggs JAG
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
Science (2016), 353(6298):506-508. doi: 10.1126/science.aaf9620
Mattei S*, Schur FKM*, Briggs JA
Retrovirus maturation-an extraordinary structural transformation
Current Opinion in Virology (2016) 18, 27-35. doi:10.1016/j.coviro.2016.02.008
Füzik T, Píchalová R, Schur, FKM, Strohalmová K, Křížová I, Hadravová, R, Rumlová M, Briggs JAG, Ulbrich P, Ruml T
Nucleic Acid Binding by Mason–Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging
Journal of Virology (2016) 90(9):4593-603. doi: 10.1128/JVI.03197-15
2015
Schur FKM*, Dick RA*, Hagen WJH, Vogt VM, Briggs JAG.
The structure of the immature-like Rous sarcoma virus Gag particles reveals a structural role for the p10 domain in assembly
Journal of Virology (2015). 89(20):10294-302. doi: 10.1128/JVI.01502-15
Schur FKM, Hagen WJ, Rumlová M, Ruml T, Müller B, Kräusslich HG, Briggs JA
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution
Nature (2015) 517:505-508. doi:10.1038/nature13838
2014
Bharat TA, Castillo Menendez LR, Hagen WJ, Lux V, Igonet S, Schorb M, Schur FKM, Kräusslich HG, Briggs JA.
Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly
PNAS (2014) 111(22):8233-8238. doi: 10.1073/pnas.1401455111
2013
Schur FKM, Hagen WJ, de Marco A, Briggs JA.
Determination of protein structure at 8.5A resolution using cryo-electron tomography and sub-tomogram averaging
Journal of Structural Biology (2013) 184(3):394-400. doi: 10.1016/j.jsb.2013.10.015
Koestler SA, Steffen A, Nemethova M, Winterhoff M, Luo N, Holleboom JM, Krupp J, Jacob, S, Vinzenz M, Schur F, Schlüter K, Gunning PW, Winkler C, Schmeiser C, Faix J, Stradal TEB, Small JV, Rottner K.
Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin
Molecular Biology of the Cell (2013). 24, 2861-2875. doi: 10.1091/mbc.E12-12-0857
Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Holleboom JM, Schur F, Small JV, Schwarz J, Gerhard R, Faix J, Stradal TEB, Brakebusch C, Rottner K
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
Journal of Cell Science (2013) 126, 4572-4588. doi: 10.1242/jcs.118232
2012
Vinzenz M, Nemethova M, Schur F, Mueller J, Narita A, Urban E, Winkler C, Schmeiser C, Koestler SA, Rottner K, Resch GP, Maeda Y, Small JV.
Actin branching in the initiation and maintenance of lamellipodia
Journal of Cell Science (2012). 125, 2775-85, doi:10.1242/jcs.107623
*equal contribution
# shared corresponding author